Midazolam Co-induction with Thiopentone and Propofol : a Comparative Study

Most commonly we use thiopentone and propofol as I.V.induction agent for General anaesthesia. They have many characteristics similar to ideal induction agent but also have dose related side effects. To decrease these side effects we may use the small dose of drug before induction which act synergistically with thiopentone and propofol in central nervous system to produce induction and the durg shonld not affect recovery. Midazolam is hypnotic sedative drug with anxiolytic and amnesic properties also it has good cardiovascular stability. So we did randomized study of midazolam as co-induction drug with induction agent thiopentone and propofol on 120 patients in four group of 30 each. Midazolam 0.05 mg/kg was given I.V. 3 minutes before induction in group II & IV while thiopentone in group I & II and propofol in group III & IV was given as induction agent. The effect of midazolam co-induction was studied in terms of induction dose and time of thiopentone and propofol with haemodynamic changes and its effect on recovery parameters using various methods. We came to conclusion that I.V. 0.05 mg/kg midazolam co-induction markedly reduces the dose requirement of induction agents (Thiopentone and Propofol) and induction time. In case of propofol it reduces the cost of anaesthetic drug without significant quality of recovery and haemodynamic changes in surgeries of more than on hour duration